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PRESCRIBED FOR: Methotrexate is used for treatment at higher doses than for other uses and is often administered intravenously or intramuscularly.

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Certolizumab pegol in combination with dose-optimised methotrexate in DMARD-naïve patients with early, active rheumatoid arthritis with poor prognostic factors: 1-year results from C-EARLY, a randomised, double-blind, placebo-controlled phase III study.

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X-rays can help in detecting RA, but may not show anything abnormal in early arthritis.

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Supplementation with folinic acid to reduce adverse effects in rheumatoid patients has been tried and has been shown to be most useful when given 24 hours following methotrexate to minimise inhibiting the therapeutic action of methotrexate.

Central Nervous System: Headaches, drowsiness, blurred vision, transient blindness, speech impairment including dysarthria and aphasia, hemiparesis, paresis and convulsions have also occurred following administration of methotrexate.

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In univariate analyses, feeling sick before or after taking MTX was significantly related to: older age, larger current MTX dose and longer duration of taking MTX.

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To evaluate efficacy and safety of combination therapy using certolizumab pegol (CZP) and methotrexate (MTX) as first-line treatment for MTX-naive, early rheumatoid arthritis (RA) with poor prognostic factors, compared with MTX alone.

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