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Adverse reactions, regardless of relationship to study drug, that were reported in at least 5% of the patients treated with Gleevec are shown in Table 14 (Study 1) and Table 15 (Study 2).

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Patients were eligible for the study if they were between 18 and 70 years of age and had received a diagnosis of chronic-phase, Ph-positive CML within six months before study entry.

The TKI resistance observed was secondary to a germline deletion polymorphism of the BH3 domain of BIM (BCL2L11) that is needed for TKIs to induce apoptosis in malignancies driven by kinases.

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The American College of Surgeons Oncology Group trial Z9001 randomized 708 patients to receive either placebo or treatment with imatinib for 1 year.

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An ultrasound-guided biopsy of the ill-defined hypoechoic area demonstrated an infiltrating ductal carcinoma.

However, when the overall death rate from GIST was shown to be low because of the efficacy of imatinib for advanced or recurrent disease, the investigators changed the endpoint to RFS.

These are not all of the possible side effects of BOSULIF.

Imatinib was invented in the late 1990s by scientists at Ciba-Geigy (which merged with Sandoz in 1996 to become ), in a team led by biochemist and that included Elisabeth Buchdunger and Jürg Zimmermann and its use to treat CML was driven by oncologist of (OHSU).

Cardioprotection and Safety of Dexrazoxane in Patients Treated for Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Advanced-Stage Lymphoblastic Non-Hodgkin Lymphoma: A Report of the Children's Oncology Group Randomized Trial Pediatric Oncology Group 9404.

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Clinical trials will explore combining imatinib mesylate with other drugs to improve the prognosis of patients with blastic-phase CML.

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Unlike two previous studies in gastrointestinal stromal tumours (GIST) patients (; ), a recent clinical pharmacokinetic (PK) substudy carried out on the basis of the B2222 trial, evaluating imatinib in patients with unresectable or metastatic CD117-positive GIST, found a correlation between imatinib total exposure and clinical response.

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By 12 months, the cumulative MR4 for the subgroup treated with imatinib at a dose of 400 mg and the PegIFN90 vs imatinib of 400-mg and PegIFN45 were 25% and 28% respectively.

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In this paper, we report the synergistic cooperation between bosutinib and imatinib in several Bcr-Abl-positive cell lines as well as in samples derived from patients with CML.

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The most frequently reported drug-related adverse reactions were edema, nausea and vomiting, muscle cramps, musculoskeletal pain, diarrhea and rash (Table 2 and Table 3 for newly diagnosed CML, Table 4 for other CML patients).

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