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When CIPRO was administered as a single 1000 mg dose concomitantly with omeprazole (40 mg once daily for three days) to 18 healthy volunteers, the mean AUC and C max of ciprofloxacin were reduced by 20% and 23%, respectively.

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Crystals of ciprofloxacin have been observed rarely in the urine of human subjects but more frequently in the urine of laboratory animals, which is usually alkaline Crystalluria related to ciprofloxacin has been reported only rarely in humans because human urine is usually acidic.

Co-treatment with grapefruit juice inhibits while chronic administration activates intestinal P-glycoprotein-mediated drug efflux.

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Theophylline: Inform patients that Ciprofloxacin may increase the effects of theophylline.

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Multidrug-resistant tuberculosis; alternative regimen for tularemia; alternative regimen for cutaneous and GI anthrax; alternative therapy for plague; disseminated gonorrhea; cystic fibrosis and gastroenteritis in children; as part of combination therapy for treating atypical mycobacterial infections; traveler's diarrhea.

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In mass casualty settings after release of biological weapons, the US CDC and Working Group on Civilian Biodefense have recommended ciprofloxacin as the drug of choice for postexposure prophylaxis and treatment of anthrax, and as an alternative for tularemia and plague.

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Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA).

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In a recently reported clinical trial whose design was similar to ours, Nickel and colleagues () found no significant difference in the NIH-CPSI total score in men treated with 6 weeks of levofloxacin compared with placebo.

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