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To our knowledge, this will be the only controlled double-blind study to date that will examine the efficacy of a serotonin and dopamine combination given from the start of treatment.

Reduction of levodopa dosage may ameliorate dyskinesia.

The results of the oft-cited Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) demonstrated that FGAs and SGAs have similar efficacy, but both groups have potentially troublesome side effects that warrant careful monitoring and can disrupt otherwise effective treatment.

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When used as monotherapy, DA agonists provide only modest improvement in parkinsonian symptoms, but the improvement may be sufficient to delay the introduction of levodopa by several months or years.

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Subscales of a quality of life measure, the Functional Status Questionnaire, showed significant improvements compared to placebo with both agonists.

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RLS patients who took pramipexole on a daily basis for over a year did not elicit any indication of obsessive behavior change since the start of medication, but considering the very large number of patients with PD necessary to demonstrate presence of this side-effect, our sample is most likely too small.

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If you are taking pramipexole to treat Parkinson's disease, take the missed dose as soon as you remember it.

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Longitudinal data from its use from 1994 through 2005 are presented as a validation for the scale, as a measure of the progressivity of PSP, and as a clinical prognostic guide.

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Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1.

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