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To our knowledge, this will be the only controlled double-blind study to date that will examine the efficacy of a serotonin and dopamine combination given from the start of treatment.
Reduction of levodopa dosage may ameliorate dyskinesia.
The results of the oft-cited Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) demonstrated that FGAs and SGAs have similar efficacy, but both groups have potentially troublesome side effects that warrant careful monitoring and can disrupt otherwise effective treatment.
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When used as monotherapy, DA agonists provide only modest improvement in parkinsonian symptoms, but the improvement may be sufficient to delay the introduction of levodopa by several months or years.
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Subscales of a quality of life measure, the Functional Status Questionnaire, showed significant improvements compared to placebo with both agonists.
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In one of these clinical trials, the rate of augmentation with placebo reflected natural fluctuations in RLS symptoms and, if anything, was slightly higher than the rate with dopaminergic medication.
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WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider.
RLS patients who took pramipexole on a daily basis for over a year did not elicit any indication of obsessive behavior change since the start of medication, but considering the very large number of patients with PD necessary to demonstrate presence of this side-effect, our sample is most likely too small.
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If you are taking pramipexole to treat Parkinson's disease, take the missed dose as soon as you remember it.
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Longitudinal data from its use from 1994 through 2005 are presented as a validation for the scale, as a measure of the progressivity of PSP, and as a clinical prognostic guide.
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The first use of the word "onanism" to consistently and specifically refer to masturbation appears to be Onania, an anonymous pamphlet first distributed in London in 1716.
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Full recovery is uncommon, especially if the illness has been present for some years.
Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1.
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