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It remains surprising that despite their pivotal role in transmission, some of the most fundamental questions about gametocyte biology remain unknown.

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The anti-IgE monoclonal antibody omalizumab is the most recent addition to the list of treatment options for these patients and has been shown to reduce exacerbations and emergency visits and improve lung function, symptom scores and quality of life in patients with difficult-to-treat asthma whose symptoms remain inadequately controlled despite receiving ICS and LABAs.

Over the last few years, the indications for systemic therapy have expanded: Systemic therapy should always be considered when other treatments have not resulted in a clinical benefit.

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